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Title   한국인에서 발생한 비호지킨 림프종에서 Epstein-Barr Virus Nuclear Antigen의 검출에 관한 연구 ( The Indidence of Epstein-Barr Virus Neclear Antigen in Sporadic Non-Hodgkin's Lymphomas of Korean )
Publicationinfo   1997 Jan; 029(03): 473-485.
Key_word   EBV, Non-Hodgkins lymphoma, Immunohistochemistry, PCR
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Abstract   Purpose: It's well known that the Epstein-Barr virus(EBV) is associated with endemic Burkitts lymphoma and B cell lymphomas in immunocompromised individuals, and undifferentiated carcinoma of the nasopharynx. A clonotypic proliferation of EBV has been demonstrated in the neoplastic cells of these malignancies, suggesting a causative role of EBV in the tumorigenesis. More recently, it was identified that EBV has been linked to Hodgkins disease and B or T-cell non-Hodgkins lymphomas(NHLs) without preexisting immunodeficiency. Material and Method: To determine the immunophenotype and incidence of EBV infection in sporadic NHLs of Korea, We investigated 90 cases of NHLs through immunohistochemistry and polymerase chain reaction, respectively. Results: Sixty-nine of 90(77%) of NHLs are of B-cell type, 18 of 90(20%) of NHLs are of T-cell type and 3 out of 90(3%) of NHLs are undefined lineage by immunohistochemistry. EBV genome was detected in 7 out of 69(10%) B-cell lyrnphomas, 5 out of 18(28%) T-cell lymphomas and 1 out of 3(33%) non-B and non-T cell lymphomas by poly merase chain reaction. The male/female ratio of EBV-positive NHLs was 2.25:1. There are no prominent differences in age distribution and tumor localization between EBV positive groups and negative groups. Conclusion: EBV positivity in T-cell NHLs is rather higher than in B-cell NHLs and this finding suggests that there is inter-relation association between EBV and T-cell NHLs, although the exact nature of this association remains to be established.
저 자   이미숙(Mi Sook Lee),전호종(Ho Jong Jun),하상호(Ha Sang Ho),최봉남(Bong nam Choi)